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Dec 4, 2023
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Best NMN Supplement: Fountain of Youth in a Bottle? (2023)

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What exactly is the big deal with NMN? It all starts with NAD (nicotinamide adenine dinucleotide). Think of NAD as cellular currency in your body. It’s required for things like energy production, DNA repair, and regulating gene expression. All of these processes sustain cell life and resist aging. As we age, our NAD levels drop, leading to a…
The post Best NMN Supplement: Fountain of Youth in a Bottle? (2023) appeared first on Breaking Muscle.

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What exactly is the big deal with NMN? It all starts with NAD (nicotinamide adenine dinucleotide). Think of NAD as cellular currency in your body. It’s required for things like energy production, DNA repair, and regulating gene expression. All of these processes sustain cell life and resist aging.

As we age, our NAD levels drop, leading to a decline in these functions. Not surprisingly, this contributes to the aging process. This is why people are trying to maintain or boost their NAD levels. Experts believe maintaining higher levels of NAD can potentially slow down aging and promote longevity. (18)

One of the ways to increase NAD levels is with NMN supplements. Nicotinamide mononucleotide (NMN) is a precursor to NAD, meaning it’s a substance that the body can convert into NAD. It’s like a raw material that cells can use to create more of the NAD ‘currency’ they need to function optimally.

With two decades of experience as a personal trainer and fitness nutrition specialist, I’ve witnessed a shift in client inquiries from how to get six-pack abs to a desire for longevity and improved quality of life. People don’t just want to live longer; they want to feel better too. While exercise and diet are important, NMN supplements offer a promising way to naturally boost NAD levels. For my review, I tested several options to help you find the best NMN supplement.

Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider.

How We Chose the Best NMN Supplements

I’d argue that choosing the best NMN supplement is more difficult than most other supplements because it hasn’t been on the market for very long. With limited time for rigorous scrutiny, finding products that truly align with the science can be a challenge.

Here at Breaking Muscle, there are several factors that we consider to ensure you get the best NMN supplements for your budget and lifestyle.

Science-Based Formulas

We give priority to products featuring ingredients backed by proven scientific evidence. 

Ingredients such as NMN, resveratrol, and vitamin D have consistently demonstrated anti-aging benefits in studies. (5)(8) (14)

What’s more, we evaluate the dosage of each ingredient, aiming to closely align it with the quantities shown in these studies for maximum effectiveness.

Third-Party Verification

Let’s face it: Supplements that undergo third-party testing instill greater confidence. 

We’ve favored products that have been through legitimate testing by independent laboratories, assuring purity and potency.

Real-World User Feedback

Real-life experiences offer invaluable insights. We’ve conducted a thorough review of user feedback, meticulously examining reports of effectiveness, benefits, and any potential drawbacks to provide you with a comprehensive assessment.

Company Reputation

The track record of a brand matters. We’ve chosen companies with a reputation for integrity, transparency, and a commitment to customer satisfaction.

Balancing Value

Our aim is to recommend supplements that strike the right balance between cost and effectiveness, ensuring you receive the best value for your investment.

Safety

Above all, your well-being is our top concern. We’ve focused on supplements that incorporate proven, safe ingredients without unnecessary additives or fillers. 

Naturally, products associated with a long history of adverse effects have been excluded from our list.

Our Top Picks for the Best NMN Supplement

Best NMN Supplement Overall: Lifeforce Peak NMN


Lifeforce Peak NMN


4.5
  • Daily dose: Three capsules
  • Cost per serving: One-time purchase: $3.00 per serving / Monthly subscription: $2.33 per serving
  • NMN per serving: 375 milligrams
  • Key ingredients: Nicotinamide mononucleotide, berberine HCl, white mulberry extract, spermidine, lithium
  • Third-party testing: No


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Pros

  • HPLC-tested NMN with 99 percent purity 
  • 24 months’ stability
  • Naturally support healthy blood sugar levels

Cons

  • Difficult to find reviews
  • Price point for a one-time purchase is expensive
  • Only available through the official website

I’ve been a big fan of Lifeforce since I tried the brand in my search for the best testosterone booster. Once again, they didn’t disappoint. In fact, the team and I were so impressed with Peak NMN that we assigned it as our best NMN supplement overall.

What clinched it for us? 

A combination of science-backed ingredients at doses that work, all without breaking the bank. Plus, Peak NMN targets something special: it not only supports long-term cellular health but also takes on blood sugar — a key factor in aging. Consistently elevated blood sugar can damage mitochondria or cellular ‘powerhouses’ and contribute to age-related diseases. (1)

Lifeforce tackles this with two key ingredients: Berberine HCl (660 milligrams) and White Mulberry Extract (200 milligrams), both proven to support healthy blood sugar levels. It also includes spermidine, which helps with cellular growth and renewal. It’s known for aiding in autophagy, the body’s way of cleaning out old cellular junk to make way for new, healthier cells. (2)(3)(4)

Naturally, Lifeforce’s star ingredient is NMN, which has been shown to boost NAD levels, helping to keep your cells strong. NAD plays a significant role in all cellular processes, most notably, energy production, DNA repair, and the regulation of cellular aging. (5)

For me, one of the features of Peak NMN that stands out from other NMN supplements is its quality and stability. It contains HPLC-tested NMN boasting 99 percent purity and a 24-month shelf life. 

Not only are you getting the highest quality form of NMN but it’s also going to last much longer than most other NMN supplements. For context, most brands of NMN have a three-month shelf life when stored at room temperature. To get around this, simply put your NMN supplement in the refrigerator.

Finally, one of my favorite features of Lifeforce supplements is the option to add a specialized home blood test that evaluates dozens of biomarkers focusing on aging and longevity. This test, supported by telehealth consultations and individualized guidance from a healthcare professional, aims to provide insights into biological age, cellular health, and factors influencing lifespan. Taking these tests before and several months after consistently using the supplement (and following the advice of the telehealth experts) can showcase how your cellular health is improving.

One of the team members at Breaking Muscle went through this Lifeforce Diagnostics test, and he was amazed at the professionalism of the team as well as the preciseness and quality of the information he received from it. He especially liked the convenience factor of having a phlebotomist come to the location of his choice. It’s very easy to schedule and the whole process takes less than 10 minutes from the comfort of your home.

Why didn’t Peak NMN get a perfect score? My only gripe with the supplement is the dosage of NMN. Sure, it provides 375 milligrams per serving, which may be enough if you’re new to NMN and want to avoid potential side effects like digestive issues and skin irritation. But what happens when your body adjusts, and you want to take a dosage closer to 1,000 milligrams (the higher end of the recommended daily dose)? 

Compare the 375 milligrams of NMN in Peak NMN to the 900 milligram serving in Wonderfeel Youngr NMN – A huge difference. If you want to get close to this when taking Peak NMN, you’ll have to either double the dose or take a separate NMN supplement. If you choose the latter, I’d recommend going with our choice for the best budget NMN supplement, GenF20 Liposomal NMN+, to save some cash.

Best NMN and Resveratrol Supplement: Omre NMN + Resveratrol


Omre NMN + Resveratrol


4.5
  • Daily dose: Two capsules
  • Cost per serving: One-time purchase: $1.99 per serving / Monthly subscription: $1.89 per serving
  • NMN per serving: 500 milligrams
  • Key ingredients: NMN powder, resveratrol, BioPerine 
  • Third-party testing: Yes


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Pros

  • Addition of BioPerine for better absorption
  • Plenty of positive reviews
  • 30-day money-back guarantee

Cons

  • No real savings with the Subscribe-and-Save option
  • Only available through the official website
  • Some of the reviews are questionable

When the longevity trend started, the abbreviations “NMN” and “NAD” were virtually unheard of. Instead, everyone was talking about resveratrol. Just because NMN is now taking center stage within the cellular health and longevity movement doesn’t mean resveratrol is obsolete. In fact, we recommend taking them both together. And that’s why our pick for the best NMN and resveratrol supplement is Omre NMN + Resveratrol.

What exactly is resveratrol?

A type of antioxidant known as a polyphenol, resveratrol is found in the skin of red grapes and berries as well as cocoa. Antioxidants fight against oxidative stress in your body, which is caused by an excess of free radicals. These are molecules that can damage cells and they are linked to several chronic diseases along with aging.

And this is where resveratrol comes in as an all-around longevity supplement. 

From a cardiovascular standpoint, resveratrol has been shown to support heart health by improving blood flow and reducing inflammation. Some research even suggests it can support healthy blood sugar levels. (Remember what we said above about blood sugar levels and aging?) (6)(7)

For our purposes, the most important benefits of resveratrol are its anti-aging properties, which include:

  • DNA repair: Activates proteins called sirtuins, aiding in DNA repair and cellular health. (8)
  • Antioxidant properties: Protects cells against oxidative stress, which contributes to aging. (9)
  • Cognitive protection: Offers neuroprotective effects that may slow neurodegenerative diseases. (10)
  • Cellular health: Improves mitochondrial function, leading to increased energy production and cellular vitality. (11)

Combining resveratrol with NMN may offer synergistic benefits. Most notably, the antioxidant activity of resveratrol complements the role of NMN in supporting mitochondrial (cellular) function.

I love the idea of combining two longevity heavy hitters. This is something you don’t see in many NMN supplements. And the fact that Omre uses trans-resveratrol earns it extra points. Why? Trans-resveratrol is the more bioavailable form of resveratrol meaning your body can properly ingest and assimilate the ingredient.

What’s more, both ingredients are dosed at 500 milligrams per serving, well within the same range used in studies and research. If you are interested in gradually building up to a higher dose, you can simply double your dose and you’ll be within the same range as longevity expert, David Sinclair.

Best Budget NMN Supplement: GenF20 Liposomal NMN+


GenF20 Liposomal NMN+


3.5
  • Daily dose: One capsule
  • Cost per serving: Annual: $0.49 per serving / Semi-annual: $0.55 per serving / One-time purchase: $1.17 per serving
  • NMN per serving: 250 milligrams
  • Key ingredients: Nicotinamide mononucleotide
  • Third-party testing: No


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Pros

  • Very budget-friendly, especially the annual plan
  • 67-day money-back guarantee
  • Good for newcomers to NMN supplements

Cons

  • Low dosage of NMN
  • No additional ingredients for bioavailability
  • Shelf stability could be a problem

If there’s one thing that you’ll quickly notice about NMN supplements, it’s the price tag. The sticker shock is going to naturally lead to the question of whether the best budget NMN supplement exists and if it’s worth buying. Thankfully, that can be answered with a double “yes.”

Introducing GenF20 Liposomal NMN+.

There are three major differences between GenF20 NMN and the rest of the options on this list: price, dosage, and bioavailability.

Let’s start with the obvious one: price. Even if you purchase a single bottle of GenF20, you’re only paying $1.17 per serving, which is half of what some of the other brands are charging. If you want an insanely good deal for inexpensive supplements, you can’t beat buying one year’s worth upfront.

But there’s a reason for the lower price point and it has to do with ingredients and dosage. The only ingredient you’ll find in GenF20 is NMN. So, if you want those other ingredients that support longevity and cellular health, you’ll have to buy them separately and build your own stack. This is something I highly recommend. Not only can it be more cost-effective, but you’re guaranteed to get the proper dosage.

Speaking of dosages, you’ll see that it’s on the lower end of what the major studies used. Most of the studies mentioned above used anywhere from 250 milligrams to 1,250 milligrams. GenF20 provides 250 milligrams of NMN, which is among the lowest on our list. It isn’t bad if you’re just starting out and you want to see how your body responds to NMN, but for the long term, you’ll need to double or triple the dosage. 

Here’s the thing about that: At this price point, that’s still a good deal! If you buy a year upfront, you can easily triple your dosage and it’ll still end up being cheaper than most of the other NMN supplements out there.

Finally, let’s talk about bioavailability, which might be a double-edged sword for GenF20. On one hand, it uses liposomal delivery technology, which can significantly enhance the absorption of NMN into the bloodstream. Liposomal delivery means that the NMN is encased in a sort of protective bubble made from lipids (fats). As a result, the NMN can bypass the harsh acids in the digestive system and get delivered directly into the cells where it’s needed most. (12)

On the other hand, not all liposomal products are created equal. The quality and size of the liposomes, as well as the stability of the liposomal structure, can greatly affect the uptake of NMN. Luckily, GenF20 claims to use high-quality liposomal encapsulation to ensure that you’re getting the most out of each serving.

One final point about bioavailability involves the shelf stability of the product. NMN supplements are notorious for having a poor shelf life. Yes, brands do spend the extra cash to ensure a longer shelf life like Lifeforce: Peak NMN. However, GenF20 doesn’t mention anything about an extended shelf life. As I mentioned above, if your aim is to take double or triple the serving size, shelf life isn’t something you’ll need to worry about.

Best Pure NMN Supplement: partiQlar Pure NMN


partiQlar Pure NMN


4.0
  • Daily dose: One capsule
  • Cost per serving: Annual: $0.71 per serving / Semi-annual: $0.90 per serving / One-time purchase: $1.20 per serving
  • NMN per serving: 500 milligrams
  • Key ingredients: Nicotinamide mononucleotide
  • Third-party testing: Yes


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Pros

  • Great dosage
  • Third-party tested
  • 60-day money-back guarantee

Cons

  • Nothing to ensure bioavailability
  • Questionable shelf stability
  • Lack of reviews

It should come as no surprise that the quality of supplements can range drastically. Take protein supplements as an example. If you buy whey protein concentrate, you might be getting a product that’s only 60% protein. If you buy whey protein isolate, you’ll get a hyper-filtered product that can deliver over 99% protein per serving. Both are protein supplements, but one is vastly superior to the other in terms of purity.

And the same goes for NMN supplements.

Purity or how much NMN you’re getting in every serving can vary wildly depending on the brand. On our list, we made sure to find products that had no less than 96% purity, which is the minimum you should always look for when shopping for an NMN supplement. With a product that pure, does it really matter which one you choose? 

Absolutely. Those last few purity points can really make a difference especially if it’s paired with a bioavailability delivery system ensuring optimal uptake.

When it comes to the best pure NMN supplement, partiQlar Pure NMN gets our vote for three reasons: a pure product, a knack for transparency, and an awesome team.

partiQlar’s NMN boasts an industry-leading purity that exceeds 99% and that’s a huge deal. This isn’t just some marketing ploy, it’s a claim that’s backed up by independent third-party laboratory testing. If you visit the official website, you’ll see that all the test results are right there on the homepage. (13)

Aside from the absurdly high purity of partiQlar’s NMN, one of the factors that I noticed is how transparent they are about the team behind the product. Not only is this pretty uncommon for NMN supplements, but you’d be hard-pressed to find this transparency with any supplement.

Knowing who is making your product means you can become a Google investigator and do your research for your own peace of mind (and to appease your supplement OCD). Very long story short: partiQlar sources their NMN from Effepharm. According to the official website, they are supposedly renowned for their research and development team of U.S. specialists along with their rigorous testing process.

Continuing with the idea of transparency and testing, partiQlar upholds rigorous standards to align with USP (United States Pharmacopeia) quality benchmarks. Also, the production facilities responsible for crafting partiQlar’s NMN are recognized by the National Sanitation Foundation (NSF) and Underwriters Laboratories (UL), reflecting adherence to the stringent Good Manufacturing Practice (GMP) guidelines.

Now, with that said, adhering to GMP guidelines is commonplace even if a supplement doesn’t specifically mention it on their website. Supplement manufacturers in the United States must adhere to GMP standards in order to operate. So, while it’s not exactly unique, it is nice to know that your supplements are in good hands.

In short, with an elite team, production facilities, and third-party testing, partiQlar is serious about the purity and effectiveness of its NMN.

Best Anti-Aging NMN Supplement: Wonderfeel Youngr NMN


Wonderfeel Youngr NMN


4.5
  • Daily dose: Two capsules
  • Cost per serving: Introductory monthly subscription: $2.43 per serving / Regular monthly subscription: $2.76 per serving / One-time purchase: $2.93 per serving
  • NMN per serving: 900 milligrams
  • Key ingredients: Nicotinamide mononucleotide, vitamin D3, trans-resveratrol, olive fruit extract, ergothioneine
  • Third-party testing: Yes


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Pros

  • Earth-friendly packaging
  • Highest dosage of NMN on our list
  • Includes vitamin D3, a known longevity vitamin

Cons

  • Confusing monthly subscription service
  • Contains vitamin D3 but doesn’t include vitamin K2
  • No money-back guarantee

On a list of NMN supplements all claiming to reduce the impacts of aging, how does one stand above the rest as the best anti-aging NMN supplement?

For us, it’s all about a multi-targeted approach to fight the signs of aging. In other words, we want to see a supplement with multiple ingredients known for longevity benefits. And that’s what sets Wonderfeel Youngr NMN apart from the rest.

NMN is one of several anti-aging ingredients in Wonderfeel Youngr NMN. Let’s break down the ingredient list, starting from the top with vitamin D3. This is one of my favorite vitamins and one that I believe most people are lacking in.

Vitamin D3 is often associated with bone health, but it does so much more than that. When it comes to anti-aging benefits, vitamin D3 enhances immune function, supports cardiovascular health, and staves off cognitive decline. (14)

For men, vitamin D3 is especially important for hormonal health as it acts as a building block for testosterone. Low levels of testosterone are associated with weight gain, muscle loss, mood swings, and fatigue – All things that are pro-aging. (15)

Most importantly for our purposes, vitamin D3 is particularly useful because it seems to help stop the build-up of certain proteins that are commonly found in older people. Also, taking extra vitamin D3 may help reduce signs of aging at the cellular level, which suggests it might help to slow down how quickly we age biologically. (14)

There is one issue with the inclusion of vitamin D3 and it’s the exclusion of vitamin K2. When you take supplements, you want to try to pair or group ingredients that have a synergistic effect. In this case, vitamin K2 improves the bioavailability of vitamin D3. I’m not saying your body won’t see any benefit from the vitamin D3 in Wonderfeel Youngr NMN, but some level of bioavailability and potential benefit could be lacking thanks to the absence of vitamin K2.

NMN is the next ingredient on the list. What I love about Wonderfeel Youngr NMN is that it provides a dosage level that’s on the higher side at 900 milligrams per serving. As mentioned above, this is close to what David Sinclair takes on a daily basis.

Next up, we have trans-resveratrol. Again, this is another homerun ingredient. Trans-resveratrol is better than traditional resveratrol because it is the more bioavailable and biologically active form of the compound. While it is the preferred form of resveratrol, it is lacking in dosage at only 100 milligrams per serving. For reference, the standard dosage starts at 250 milligrams.

The next ingredient is olive fruit extract, which contains hydroxytyrosol, a powerful antioxidant that supports cardiovascular health by promoting healthy cholesterol levels and blood flow (circulation). It also has a lot of polyphenols and these compounds offer protective effects against oxidative stress—a key factor in aging—and inflammation, contributing to overall longevity. (16)

Finally, the ingredient list caps off with a super antioxidant known as ergothioneine, offering benefits for anti-aging, vascular health, and neuroprotection. It combats oxidative stress and inflammation, which reduces age-related cellular damage. It’s also thought to preserve telomeres, the chromosome endcaps that typically shorten with age. (17)

Cementing its place as the best anti-aging NMN supplement, is there anything that could make this supplement better? 

You bet! It is the first supplement on our list that focuses on earth-friendly packaging. Your first order will arrive in a durable and refillable glass bottle. After that, you’ll receive your supplement in completely recyclable and biodegradable pouches. Simply refill the glass bottle and recycle the pouch. Even if the pouch winds up in the garbage, it will break down within six to 42 months, leaving behind no trace of microplastics.

Do something positive for yourself while doing something productive for the environment.

What Is NMN?

Aside from being almost impossible to pronounce correctly on the first try, nicotinamide adenine dinucleotide (NAD) has an essential role in all cellular functions. 

The catch is that NAD levels naturally decline as you get older. This can lead to a variety of age-related health issues like slowing metabolism and cellular dysfunction. In a vicious cycle, the less NAD you have, the worse these issues get and the faster you age.

Enter nicotinamide mononucleotide, or NMN, a precursor to NAD. 

Put simply, NMN is what your body uses to make more NAD. Recent studies and praise from longevity experts like David Sinclair have sparked interest in NMN supplements to naturally boost NAD levels. 

The goal? To fight back against age-related decline in cellular health while improving overall longevity.

Benefits of Taking NMN

As a precursor to NAD, research suggests several potential health benefits associated with NMN supplementation:

Anti-Aging and Longevity 

NMN has exhibited numerous potential benefits against aging in different animal studies, including better metabolism and protection against diseases that come with age. Research suggests it may boost energy management within the body and enhance the body’s response to insulin as well as overall blood fat levels. (19)

Increased Energy Metabolism and Physical Activity

Supplementation with NMN has been suggested to improve energy expenditure and physical activity. A study indicated that NMN supplementation enhances neuronal function and physical activity, suggesting it may prevent the decline in energy metabolism associated with aging​​. (20)

Enhanced Physical Endurance and Metabolism

Continuing with the point above, research has found that NMN supplementation can improve endurance capacity, particularly in amateur runners, by enhancing oxygen delivery to muscle tissue and bringing energy to cells that are depleted during exercise​​. (20)

Cognitive and Cardiovascular Health

NMN supplementation has been linked to improved neuronal function in the brain and is suggested to have preventive and therapeutic potential in vascular cognitive impairment. (21)

How Long Does It Take for NMN to Start Working?

The one thing that I can’t stress enough is that NMN supplements are not like your favorite pre-workout supplements. You’re not going to feel them kick in with a bang after 20 minutes.

While several prominent biohackers suggest that you can use NMN as a nootropic (cognitive focus) supplement, I don’t agree with this. I believe the idea with NMN supplements is to promote improved cognitive function over the long term.

Besides, most nootropic-focused NMN supplements also contain other fast-acting ingredients that you’ll feel right away like caffeine and theobromine. Be sure not to confuse longevity supplements with nootropics.

It’s important to keep in mind that NMN is a long-term investment in your cellular health and overall longevity. So, don’t get discouraged if you don’t see immediate results. Stay consistent with your NMN supplement. The best way to determine if NMN is working for you is to take a biological age test once every several months and compare the differences. As mentioned above, we highly recommend Lifeforce Diagnostic, which measures more than 40 biomarkers and includes a personalized plan to optimize your health.

What Is the Best Way to Take NMN?

Hands down, the gold standard of absorption is intravenous. If you have the money and the time, you can find NAD drips at your local health spa. The results are immediate with many people citing a difference in how they feel the same day and throughout the week. The catch? NAD drips are notorious for making you nauseous. They are also extremely pricey. 

The simpler and more affordable way is with the NMN supplement.

NMN can be a bit finicky when it comes to how it’s best absorbed. The consensus is that sublingual (under the tongue) absorption is the way to go. This method allows NMN to bypass your digestive system and head straight into your bloodstream for faster results.

How Much NMN Should I Take Per Day?

This really depends on how comfortable you are with taking a “David Sinclair dose.” Some people jump right into taking 1,000 milligrams per day. 

But if you want to play it safe, many beginners start with around 250 milligrams to 500 milligrams per day. This is a good baseline to see how your body responds. As you continue to take the NMN supplement, you can gradually increase the dosage, but only if it makes sense for your goals and budget. 

What To Consider When Looking for an NMN Supplement

When shopping for an NMN supplement, here are some of the key factors to keep in mind:

Your Goals

When looking for an NMN supplement, I suggest asking yourself, “What do I want to accomplish by taking this?” 

  • Do you want to support long-term longevity in your body and brain? 
  • Are you looking to lower your biological (cellular) age?
  • Or are you looking for something fast-acting that can help you focus?

If the first two goals sound like what you’re after, then an NMN supplement can be a great complement to a healthy diet and exercise program.

If you’re more interested in that third goal, an NMN supplement isn’t going to give you what you’re after. As I mentioned above, although NMN is sometimes marketed as a nootropic, it’s not going to give you a feeling comparable to caffeine. Only stimulants will do that and NMN is not a stimulant.

So, before you buy an NMN supplement, make sure it aligns with what you’re trying to accomplish in your health journey.

The typical dosage for NMN supplements ranges between 250 milligrams and 1,250 milligrams. 

Should you start with a lower dosage? That really depends on your comfort level. 

Plenty of people jump right into taking 1,000 milligrams per day without any issues. If you’re someone who is new to NMN or supplements in general, consider starting out with 250 milligrams. If your body responds well to this dosage for a few weeks, gradually increase it. You can do that by simply doubling the serving that you’re currently taking.

With all that said, always consider speaking with a healthcare provider to help tailor your choice of the proper dosage based on your medical history and goals.

Ingredients and Ingredient Quality

You know you want to take an NMN supplement and you’re confident about the dosage. Now it’s time to make sure you’re getting quality ingredients. 

Here are several factors to look for when buying an NMN supplement:

  • Purity: Buy an NMN supplement that contains at least 96 percent purity.
  • Third-party testing: Look for products that have been third-party tested for quality assurance.
  • Certifications: Certifications such as GMP or NSF signify a product’s high-quality manufacturing.
  • Complementary ingredients: Check that added ingredients enhance efficacy and offer additional health benefits.
  • Additives and fillers: Avoid supplements with unnecessary additives, fillers, or any low-quality ingredients.
  • Product reviews and company reputation: Research the manufacturer’s reputation and read customer reviews to gauge the effectiveness and reliability of the product.

Safety

NMN supplements shouldn’t be a gamble. You should be able to confidently take your choice of supplement without worrying about your safety. 

Here are some tips to keep yourself safe when shopping for NMN supplements:

  • Check for interactions with medications. If you are currently taking medication, it’s crucial to understand how NMN might interact with those medications. Consult with a healthcare provider to ensure there are no potential negative interactions.
  • Ensure the supplement is backed by clinical research. Look for supplements that have been supported by clinical research. While research on NMN is still emerging, some products may have more scientific backing than others.
  • Ensure the brand adheres to safe manufacturing standards. Check to see if the supplement is produced in facilities that follow high safety standards, such as GMP-certified facilities. This ensures that the product is made with a high degree of consistency and control.

Potential Side Effects

NMN supplements are usually very safe and easy to handle. Still, some side effects have been reported, including the following:

  • Digestive issues such as nausea, vomiting, diarrhea, and abdominal pain
  • Gastrointestinal discomfort, including bloating and indigestion
  • Skin irritation and allergic reactions
  • Flushing and headaches

If you experience any of these, reducing the dosage or discontinuing use may be necessary. Either way, I’d recommend speaking with your doctor. Also, be sure to check the ingredient label to ensure the side effects are coming from the NMN and not another ingredient.

If you’re concerned about the potential side effects of NMN supplements, start with a lower dosage like 250 milligrams, and gradually increase it to gauge your body’s tolerance. Keep a close watch on your body’s reactions after starting NMN supplementation. Any new or unexpected symptoms should be taken seriously and discussed with a healthcare provider.

How To Get the Best Results from an NMN Supplement

There’s more to throwing a supplement capsule in your mouth and going about your day. If you want to get the most from your NMN supplement, here are several tips to consider:

Be Consistent

Above all, if you want to see results, you need to be consistent with taking your supplement. When taken at the same time each day, NMN supplements can help maintain stable levels of NAD in the body. 

In addition to consistency, the timing of your NMN dose might play a role in its efficacy. (And I stress the word “might.”)

There’s some evidence to suggest that taking NMN in the morning could align with your body’s natural rhythms for producing NAD. 

On the other hand, I’ve read that some experts recommend taking NMN at night to help with sleep. 

Does it matter? Overall, I’d recommend finding a time that works best for you and sticking with it. Better to be consistent with taking the supplement than trying to time it perfectly amidst a chaotic schedule and missing doses.

Remember That Diet and Exercise Come First 

Don’t forget, supplements are just part of the equation. As I always say to my clients, “Supplements are supplemental.” They should never be the star of the show – That privilege belongs to diet and exercise.

Eating right and staying active are essential if you want to see the best results. Before considering supplements, I’d suggest reviewing your current fitness and meal plan. Could they use some work? If so, then focus your time, energy, and money on those first.

Once your foundations with food and fitness are solid, then you can bring supplements into the mix.

Consider Synergistic Supplements

Assuming your diet and exercise program are all taken care of, you can look at longevity supplements beyond NMN.

While incredible on its own, NMN can be part of a broader supplement strategy. For example, combining NMN with resveratrol, a compound that also supports cellular health, may enhance the effects of NMN.

This isn’t a requirement but something to consider if your goal is to optimize anti-aging benefits and longevity.

Monitoring Progress and Adjust

Finally, I’d recommend keeping track of how you feel before and after starting the NMN supplement. Use the notepad on your phone and track any changes in energy levels, cognitive function, and overall wellness to gauge the supplement’s effectiveness.

Outside of noting how you feel, if you’re serious about tracking your results, I’d suggest a biomarkers panel test like the one Lifeforce offers. Doing this every quarter or every six months will give you the best idea of how you’re progressing and the changes you might need to make, especially if you’re chatting with a longevity expert.

Final Thoughts

I’m glad that longevity is finally a big focus in the industry. I’m ecstatic when clients ask me questions about living a longer life AND feeling better during those extended years.

Most importantly, I believe that NMN supplements have the potential to play an important role in achieving those anti-aging goals.

However, I’m still a big believer in the basics. 

There’s no “magic pill” that’s going to keep you young forever — at least, not yet there isn’t. Until that day arrives, I can’t stress this enough: Focus on mastering your nutritional choices, get consistent with an exercise program, and consider mental health exercises like meditation so you can live a well-balanced, healthy life. Once these are in order, you can complement your lifestyle with NMN supplements.

Best NMN Supplement: Side-by-Side Comparison

Best NMN Supplement Overall

Best NMN and Resveratrol Supplement

Best Budget NMN Supplement

Best Pure NMN Supplement

Best Anti-Aging NMN Supplement


4.5



4.5



3.5



4.0



4.5


Description:

  • Daily dose: Three capsules
  • Cost per serving: One-time purchase: $3.00 per serving / Monthly subscription: $2.33 per serving
  • NMN per serving: 375 milligrams
  • Key ingredients: Nicotinamide mononucleotide, berberine HCl, white mulberry extract, spermidine, lithium
  • Third-party testing: No

Description:

  • Daily dose: Two capsules
  • Cost per serving: One-time purchase: $1.99 per serving / Monthly subscription: $1.89 per serving
  • NMN per serving: 500 milligrams
  • Key ingredients: NMN powder, resveratrol, BioPerine 
  • Third-party testing: Yes

Description:

  • Daily dose: One capsule
  • Cost per serving: Annual: $0.49 per serving / Semi-annual: $0.55 per serving / One-time purchase: $1.17 per serving
  • NMN per serving: 250 milligrams
  • Key ingredients: Nicotinamide mononucleotide
  • Third-party testing: No

Description:

  • Daily dose: One capsule
  • Cost per serving: Annual: $0.71 per serving / Semi-annual: $0.90 per serving / One-time purchase: $1.20 per serving
  • NMN per serving: 500 milligrams
  • Key ingredients: Nicotinamide mononucleotide
  • Third-party testing: Yes

Description:

  • Daily dose: Two capsules
  • Cost per serving: Introductory monthly subscription: $2.43 per serving / Regular monthly subscription: $2.76 per serving / One-time purchase: $2.93 per serving
  • NMN per serving: 900 milligrams
  • Key ingredients: Nicotinamide mononucleotide, vitamin D3, trans-resveratrol, olive fruit extract, ergothioneine
  • Third-party testing: Yes

Best NMN Supplement Overall


4.5


Description:

  • Daily dose: Three capsules
  • Cost per serving: One-time purchase: $3.00 per serving / Monthly subscription: $2.33 per serving
  • NMN per serving: 375 milligrams
  • Key ingredients: Nicotinamide mononucleotide, berberine HCl, white mulberry extract, spermidine, lithium
  • Third-party testing: No

Best NMN and Resveratrol Supplement


4.5


Description:

  • Daily dose: Two capsules
  • Cost per serving: One-time purchase: $1.99 per serving / Monthly subscription: $1.89 per serving
  • NMN per serving: 500 milligrams
  • Key ingredients: NMN powder, resveratrol, BioPerine 
  • Third-party testing: Yes

Best Budget NMN Supplement


3.5


Description:

  • Daily dose: One capsule
  • Cost per serving: Annual: $0.49 per serving / Semi-annual: $0.55 per serving / One-time purchase: $1.17 per serving
  • NMN per serving: 250 milligrams
  • Key ingredients: Nicotinamide mononucleotide
  • Third-party testing: No

Best Pure NMN Supplement


4.0


Description:

  • Daily dose: One capsule
  • Cost per serving: Annual: $0.71 per serving / Semi-annual: $0.90 per serving / One-time purchase: $1.20 per serving
  • NMN per serving: 500 milligrams
  • Key ingredients: Nicotinamide mononucleotide
  • Third-party testing: Yes

Best Anti-Aging NMN Supplement


4.5


Description:

  • Daily dose: Two capsules
  • Cost per serving: Introductory monthly subscription: $2.43 per serving / Regular monthly subscription: $2.76 per serving / One-time purchase: $2.93 per serving
  • NMN per serving: 900 milligrams
  • Key ingredients: Nicotinamide mononucleotide, vitamin D3, trans-resveratrol, olive fruit extract, ergothioneine
  • Third-party testing: Yes

FAQs

What is the best form of NMN to take?

The best form of NMN to take typically depends on individual preferences and absorption rates; however, sublingual (under the tongue) tablets or powders are often recommended because they can bypass the digestive system and go directly into the bloodstream, potentially offering more immediate and effective absorption.

Which brand of NMN does David Sinclair take?

David Sinclair, a prominent researcher in the field of genetics and longevity, has mentioned using NMN supplements in his regimen, but due to promotional guidelines and the potential for conflict of interest, he does not endorse a specific brand.

Is it better to take NMN or an NAD supplement?

I find that choosing between NMN and NAD supplements comes down to time, energy, and cost. Nothing beats an intravenous NAD drip, but these are expensive, and they are guaranteed to make you feel nauseous. They could also be tricky to find depending on where you live.
If you want to avoid the hassle and cost of an NAD drip, I’d opt for NMN supplements. NMN is a precursor to NAD, meaning it converts into NAD in the body.

Does NMN work without resveratrol?

NMN can function and provide benefits independently of resveratrol; however, the combination of NMN and resveratrol may have a synergistic effect, potentially enhancing each other’s efficacy in supporting cellular health and longevity.

Is NMN safe to take?

NMN can function and provide benefits independently of resveratrol; however, the combination of NMN and resveratrol may have a synergistic effect, potentially enhancing each other’s efficacy in supporting cellular health and longevity.

Research

  1. Rungratanawanich, W., Qu, Y., Wang, X. et al. Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury. Exp Mol Med 53, 168–188 (2021). https://doi.org/10.1038/s12276-021-00561-7.
  2. Liang Y, Xu X, Yin M, Zhang Y, Huang L, Chen R, Ni J. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J. 2019 Jan 28;66(1):51-63. doi: 10.1507/endocrj.EJ18-0109. Epub 2018 Nov 3. PMID: 30393248.
  3. Thondre, P.S., Lightowler, H., Ahlstrom, L. et al. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 18, 41 (2021). https://doi.org/10.1186/s12986-021-00571-2.
  4. Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102. PMID: 29955838.
  5. Igarashi, M., Nakagawa-Nagahama, Y., Miura, M. et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. npj Aging 8, 5 (2022). https://doi.org/10.1038/s41514-022-00084-z.
  6. Tomé-Carneiro J, Gonzálvez M, Larrosa M, Yáñez-Gascón MJ, García-Almagro FJ, Ruiz-Ros JA, García-Conesa MT, Tomás-Barberán FA, Espín JC. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 2012 Aug 1;110(3):356-63. doi: 10.1016/j.amjcard.2012.03.030. Epub 2012 Apr 19. PMID: 22520621.
  7. Zhu X, Wu C, Qiu S, Yuan X, Li L. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab (Lond). 2017 Sep 22;14:60. doi: 10.1186/s12986-017-0217-z. PMID: 29018489; PMCID: PMC5610395.
  8. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun;5(6):493-506. doi: 10.1038/nrd2060. Epub 2006 May 26. PMID: 16732220.
  9. Leonard SS, Xia C, Jiang BH, Stinefelt B, Klandorf H, Harris GK, Shi X. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26. doi: 10.1016/j.bbrc.2003.08.105. PMID: 13679076.
  10. Jang JH, Surh YJ. Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med. 2003 Apr 15;34(8):1100-10. doi: 10.1016/s0891-5849(03)00062-5. PMID: 12684095.
  11. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22. doi: 10.1016/j.cell.2006.11.013. Epub 2006 Nov 16. PMID: 17112576.
  12. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021 Dec;31(4):356-364. doi: 10.1080/08982104.2020.1820521. Epub 2020 Oct 6. PMID: 32901526.
  13. “Quality.” partiQlar, 6 Jan. 2023, partiqlar.com/quality/.
  14. Fantini C, Corinaldesi C, Lenzi A, Migliaccio S, Crescioli C. Vitamin D as a Shield against Aging. Int J Mol Sci. 2023 Feb 25;24(5):4546. doi: 10.3390/ijms24054546. PMID: 36901976; PMCID: PMC10002864.
  15. Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5. doi: 10.1055/s-0030-1269854. Epub 2010 Dec 10. PMID: 21154195.
  16. D’Angelo C, Franceschelli S, Quiles JL, Speranza L. Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases. Cells. 2020 Aug 21;9(9):1932. doi: 10.3390/cells9091932. PMID: 32825589; PMCID: PMC7565717.
  17. Paul BD. Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles? Antioxid Redox Signal. 2022 Jun;36(16-18):1306-1317. doi: 10.1089/ars.2021.0043. Epub 2021 Dec 7. PMID: 34619979; PMCID: PMC9221166.
  18. Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integr Med (Encinitas). 2020 Feb;19(1):12-14. PMID: 32549859; PMCID: PMC7238909.
  19. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PMID: 28068222; PMCID: PMC5668137.
  20. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021 Jul 8;18(1):54. doi: 10.1186/s12970-021-00442-4. PMID: 34238308; PMCID: PMC8265078.
  21. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. PMID: 31015147; PMCID: PMC6477631.

The post Best NMN Supplement: Fountain of Youth in a Bottle? (2023) appeared first on Breaking Muscle.

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